The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders.

Détails

ID Serval
serval:BIB_0050CE3CCC79
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders.
Périodique
Frontiers in bioengineering and biotechnology
Auteur(s)
Angelova M.T., Dimitrova D.G., Dinges N., Lence T., Worpenberg L., Carré C., Roignant J.Y.
ISSN
2296-4185 (Print)
ISSN-L
2296-4185
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
6
Pages
46
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Analogous to DNA methylation and histone modifications, RNA modifications represent a novel layer of regulation of gene expression. The dynamic nature and increasing number of RNA modifications offer new possibilities to rapidly alter gene expression upon specific environmental changes. Recent lines of evidence indicate that modified RNA molecules and associated complexes regulating and "reading" RNA modifications play key roles in the nervous system of several organisms, controlling both, its development and function. Mutations in several human genes that modify transfer RNA (tRNA) have been linked to neurological disorders, in particular to intellectual disability. Loss of RNA modifications alters the stability of tRNA, resulting in reduced translation efficiency and generation of tRNA fragments, which can interfere with neuronal functions. Modifications present on messenger RNAs (mRNAs) also play important roles during brain development. They contribute to neuronal growth and regeneration as well as to the local regulation of synaptic functions. Hence, potential combinatorial effects of RNA modifications on different classes of RNA may represent a novel code to dynamically fine tune gene expression during brain function. Here we discuss the recent findings demonstrating the impact of modified RNAs on neuronal processes and disorders.
Mots-clé
Nm, RNA modification, disease, m5C, m6A, neurons, pseudouridine
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/10/2019 12:38
Dernière modification de la notice
29/10/2019 6:26
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