A double-blind double-dummy study of citalopram comparing infusion versus oral administration.
Détails
ID Serval
serval:BIB_FFFE34C52B92
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A double-blind double-dummy study of citalopram comparing infusion versus oral administration.
Périodique
Journal of affective disorders
ISSN
0165-0327 (Print)
ISSN-L
0165-0327
Statut éditorial
Publié
Date de publication
06/1998
Peer-reviewed
Oui
Volume
49
Numéro
3
Pages
203-210
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Publication Status: ppublish
Résumé
This study compares antidepressant efficacy and tolerability of citalopram given either orally or as a slow drop infusion.
Citalopram (40 mg/day) was administered double-blindly as tablets or slow-drop infusion during the first 10 days and then open, orally, up to treatment Day 42.
In 60 moderately to severely depressed patients, the Hamilton depression total score (17-items) at baseline was 23.9 and 23.6 in the active infusion (n = 30) and active tablet (n = 30) group, respectively. These scores dropped in both groups to 15.6 and 16.9 on Day 10, and to 10.3 and 10.2 on Day 42. Response rates (delta Hamilton > or = 50%) amounted to 33.3% and 17.9% on Day 10, and 66.2% and 63.3% on Day 42, without a relevant group difference in citalopram plasma concentration.
Slow-drop infusion with citalopram shows a similar risk/benefit relationship to oral citalopram. The design of this study allowed us to evaluate pharmacological but not psychological factors which may contribute to response to slow-drop infusion.
Citalopram (40 mg/day) was administered double-blindly as tablets or slow-drop infusion during the first 10 days and then open, orally, up to treatment Day 42.
In 60 moderately to severely depressed patients, the Hamilton depression total score (17-items) at baseline was 23.9 and 23.6 in the active infusion (n = 30) and active tablet (n = 30) group, respectively. These scores dropped in both groups to 15.6 and 16.9 on Day 10, and to 10.3 and 10.2 on Day 42. Response rates (delta Hamilton > or = 50%) amounted to 33.3% and 17.9% on Day 10, and 66.2% and 63.3% on Day 42, without a relevant group difference in citalopram plasma concentration.
Slow-drop infusion with citalopram shows a similar risk/benefit relationship to oral citalopram. The design of this study allowed us to evaluate pharmacological but not psychological factors which may contribute to response to slow-drop infusion.
Mots-clé
Administration, Oral, Adolescent, Adult, Aged, Antidepressive Agents/administration & dosage, Antidepressive Agents/pharmacokinetics, Antidepressive Agents/therapeutic use, Citalopram/administration & dosage, Citalopram/pharmacokinetics, Citalopram/therapeutic use, Depressive Disorder/drug therapy, Depressive Disorder/metabolism, Double-Blind Method, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Psychiatric Status Rating Scales, Treatment Outcome
Pubmed
Web of science
Création de la notice
16/02/2020 14:22
Dernière modification de la notice
15/04/2023 6:51