Antagonizing and measurement: approaches to understanding of hemodynamic effects of kinins

Détails

ID Serval
serval:BIB_FF96D40E12AA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Antagonizing and measurement: approaches to understanding of hemodynamic effects of kinins
Périodique
Journal of Cardiovascular Pharmacology
Auteur(s)
Pellacani  A., Brunner  H. R., Nussberger  J.
ISSN
0160-2446 (Print)
Statut éditorial
Publié
Date de publication
1992
Volume
20 Suppl 9
Pages
S28-34
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Résumé
Hemodynamic effects of the kallikrein-kinin system can be investigated by experimental administration of specific kinin antagonists and by measurement of kinin levels in the circulating blood. In conscious normal rats, the bradykinin analog B4162 blunts the hypotensive effect of exogenous bradykinin. This kinin antagonist has no blood pressure effect in control rats, but it enhances the pressor effect of vasoconstrictor substances such as vasopressin or angiotensin II when they are infused at subpressor doses. Endogenous kinins may therefore participate in blood pressure regulation by antagonizing pressor substances. Plasma levels of endogenous kinins are normally in the low picomolar range. They are rapidly generated and destroyed in biological fluids. Thus, measurement of plasma kinins requires sensitive assays based on high-affinity antibodies and careful sample-handling techniques. Nonpolar solid-phase extraction on phenylsilylsilica provides a rapid, reliable, and easy extraction of kinins from plasma with constant and high recoveries.
Mots-clé
Amino Acid Sequence Animals Blood Pressure/drug effects Bradykinin/*analogs & derivatives/antagonists & inhibitors/blood/pharmacology/*physiology *Hemodynamic Processes/drug effects Humans Kallikrein-Kinin System/*physiology Kallikreins/metabolism Kinins/antagonists & inhibitors/*blood/physiology Molecular Sequence Data Rats Vasoconstriction/drug effects
Pubmed
Web of science
Création de la notice
05/03/2008 16:40
Dernière modification de la notice
20/08/2019 16:29
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