Altered high-energy phosphate metabolism predicts contractile dysfunction and subsequent ventricular remodeling in pressure-overload hypertrophy mice.

Détails

ID Serval
serval:BIB_FF86C7EC3E26
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Altered high-energy phosphate metabolism predicts contractile dysfunction and subsequent ventricular remodeling in pressure-overload hypertrophy mice.
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur⸱e⸱s
Maslov M.Y., Chacko V.P., Stuber M., Moens A.L., Kass D.A., Champion H.C., Weiss R.G.
ISSN
0363-6135[print], 0363-6135[linking]
Statut éditorial
Publié
Date de publication
2007
Volume
292
Numéro
1
Pages
H387-H391
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
To study the role of early energetic abnormalities in the subsequent development of heart failure, we performed serial in vivo combined magnetic resonance imaging (MRI) and (31)P magnetic resonance spectroscopy (MRS) studies in mice that underwent pressure-overload following transverse aorta constriction (TAC). After 3 wk of TAC, a significant increase in left ventricular (LV) mass (74 +/- 4 vs. 140 +/- 26 mg, control vs. TAC, respectively; P < 0.000005), size [end-diastolic volume (EDV): 48 +/- 3 vs. 61 +/- 8 microl; P < 0.005], and contractile dysfunction [ejection fraction (EF): 62 +/- 4 vs. 38 +/- 10%; P < 0.000005] was observed, as well as depressed cardiac energetics (PCr/ATP: 2.0 +/- 0.1 vs. 1.3 +/- 0.4, P < 0.0005) measured by combined MRI/MRS. After an additional 3 wk, LV mass (140 +/- 26 vs. 167 +/- 36 mg; P < 0.01) and cavity size (EDV: 61 +/- 8 vs. 76 +/- 8 microl; P < 0.001) increased further, but there was no additional decline in PCr/ATP or EF. Cardiac PCr/ATP correlated inversely with end-systolic volume and directly with EF at 6 wk but not at 3 wk, suggesting a role of sustained energetic abnormalities in evolving chamber dysfunction and remodeling. Indeed, reduced cardiac PCr/ATP observed at 3 wk strongly correlated with changes in EDV that developed over the ensuing 3 wk. These data suggest that abnormal energetics due to pressure overload predict subsequent LV remodeling and dysfunction.
Mots-clé
Adenosine Triphosphate/metabolism, Animals, Cardiomyopathy, Hypertrophic/complications, Cardiomyopathy, Hypertrophic/metabolism, Energy Metabolism, Hypertrophy, Left Ventricular/etiology, Hypertrophy, Left Ventricular/metabolism, Male, Metabolic Clearance Rate, Mice, Mice, Inbred C57BL, Myocardial Contraction, Phosphocreatine/metabolism, Ventricular Dysfunction, Left/etiology, Ventricular Dysfunction, Left/metabolism, Ventricular Remodeling
Pubmed
Web of science
Création de la notice
02/03/2010 17:04
Dernière modification de la notice
20/08/2019 17:29
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