Humoral responses to defined malaria antigens in children living since birth under insecticide treated curtains in Burkina Faso

Détails

ID Serval
serval:BIB_FF5F491A9DF5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Humoral responses to defined malaria antigens in children living since birth under insecticide treated curtains in Burkina Faso
Périodique
Acta Tropica
Auteur(s)
Nebie  I., Cuzin-Ouattara  N., Diallo  D. A., Cousens  S. N., Theisen  M., Corradin  G., Traore  A. S., Esposito  F.
ISSN
0001-706X (Print)
Statut éditorial
Publié
Date de publication
09/2003
Volume
88
Numéro
1
Pages
17-25
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
Insecticide treated materials (ITM) are considered a useful malaria control measure for endemic countries, but whether they also delay the acquisition of immunity to malaria remains unclear. This study investigates plasma antibody levels in 160 children aged 3-6 years from five villages protected by insecticide treated curtains (ITC) over 6 years and in 184 children of the same age group from five villages in the same area never covered by ITC. The antigens to which antibodies were investigated were: the Plasmodium falciparum circumsporozoite protein (CSP) repetitive sequence (NANP)5; the C-terminal domain of the P. falciparum exported protein 1 (Cter-PfExp1); three fragments of the glutamate rich protein (GLURP), referred to as R0, R1 and R2; the merozoite surface protein 3 (MSP3). The level of antibodies was lower in children from the ITC area than in children from the non-ITC area for (NANP)5, R0, R2 and MSP3. Prevalence and intensity of P. falciparum infection were similar in the two groups of children. These findings suggest that reducing the level of malaria transmission over a long period may affect the level of antibodies in children to both sporozoite and blood stage malaria antigens.
Mots-clé
Animals Antibody Formation Antigens, Protozoan/*blood Burkina Faso/epidemiology Child Child, Preschool Enzyme-Linked Immunosorbent Assay Female Humans Malaria, Falciparum/epidemiology/*immunology/prevention & control Male *Mosquito Control Plasmodium falciparum/*immunology Prevalence
Pubmed
Web of science
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
20/08/2019 17:29
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