Reprocessed uranium exposure and lung cancer risk.

Détails

ID Serval
serval:BIB_FECAB975821B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reprocessed uranium exposure and lung cancer risk.
Périodique
Health physics
Auteur(s)
Guseva Canu Irina, Jacob Sophie, Cardis Elisabeth, Wild Pascal, Caër-Lorho Sylvaine, Auriol Bernard, Laurier Drominique, Tirmarche Margot
ISSN
1538-5159 (Electronic)
ISSN-L
0017-9078
Statut éditorial
Publié
Date de publication
09/2010
Peer-reviewed
Oui
Volume
99
Numéro
3
Pages
308-313
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
This study investigated the risk of lung cancer in regards to protracted occupational exposure to reprocessed uranium compounds. Two thousand seven hundred and nine male workers employed at the AREVA NC uranium processing plant between 1960 and 2005 in France were included in the cohort. Historical exposure to reprocessed uranium compounds classified by their solubility type was assessed on the basis of the plant's specific job-exposure matrix. Cox proportional hazard models adjusted for attained age, calendar period, and socioeconomic status were used to estimate relative risks in regards of each type of uranium compound. The relative risk of lung cancer tended to increase with decreasing solubility of reprocessed uranium compounds. The highest-though not statistically significant-relative risk was observed among workers exposed to slowly soluble reprocessed uranium dioxide. This study is the first suggesting an increasing risk of lung cancer associated with exposure to reprocessed uranium. Our results are consistent with data from experimental studies of biokinetics and the action mechanism of slowly soluble uranium compounds, but need to be confirmed in larger studies with more detailed dose-response analyses.

Mots-clé
Cohort Studies, Follow-Up Studies, France/epidemiology, Humans, Lung Neoplasms/chemically induced, Lung Neoplasms/epidemiology, Lung Neoplasms/metabolism, Lung Neoplasms/mortality, Male, Neoplasms, Radiation-Induced/chemically induced, Neoplasms, Radiation-Induced/epidemiology, Neoplasms, Radiation-Induced/metabolism, Neoplasms, Radiation-Induced/mortality, Nuclear Power Plants, Occupational Exposure/adverse effects, Proportional Hazards Models, Risk, Solubility, Time Factors, Uranium/adverse effects, Uranium/pharmacokinetics, Uranium Compounds/adverse effects, Uranium Compounds/pharmacokinetics
Pubmed
Web of science
Création de la notice
12/09/2017 15:16
Dernière modification de la notice
20/08/2019 16:29
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