Labelling of dying neurones by peroxidase injected intravascularly in chick embryos.

Détails

ID Serval
serval:BIB_FE978CD7C5BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Labelling of dying neurones by peroxidase injected intravascularly in chick embryos.
Périodique
Neuroscience Letters
Auteur(s)
Clarke P.G.H.
ISSN
0304-3940[print], 0304-3940[linking]
Statut éditorial
Publié
Date de publication
1982
Volume
30
Numéro
3
Pages
223-228
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jun 30
Résumé
Three lines of evidence indicate that intravascularly injected horseradish peroxidase labels dying neurones selectively in the developing isthmo-optic nucleus: (i) in unoperated embryos, labelled neurones are found only during the period of normal neuronal death; (ii) some of the labelled neurones are manifestly necrotic; (iii) an intraocular injection of colchicine causes essentially all the isthmo-optic neurones to degenerate, and then they almost all take up peroxidase. However, deafferenting the developing isthmo-optic nucleus by a tectal lesion increases the loss of neurones whilst scarcely affecting the number labelled; this implies that the neurones which die because of the deafferentation either do not take up the peroxidase or are phagocytozed exceptionally rapidly.
Mots-clé
Animals, Brain/embryology, Brain/pathology, Chick Embryo, Horseradish Peroxidase, Kinetics, Nerve Regeneration, Neurons/physiology, Superior Colliculi/physiology
Pubmed
Web of science
Création de la notice
20/01/2008 17:49
Dernière modification de la notice
20/08/2019 16:29
Données d'usage