This paper tests a situational hypothesis which postulates that the number of femicides should increase as an unintended consequence of the COVID-19-related lockdowns. The monthly data on femicides from 2017 to 2020 collected in six Spanish-speaking countries-Argentina, Chile, Paraguay, Panama, Mexico, and Spain-and analyzed using threshold models indicate that the hypothesis must be rejected. The total number of femicides in 2020 was similar to that recorded during each of the three previous years, and femicides did not peak during the months of the strictest lockdowns. In fact, their monthly distribution in 2020 did not differ from the seasonal distribution of femicides in any former year. The discussion criticizes the current state of research on femicide and its inability to inspire effective criminal polices. It also proposes three lines of intervention. The latter are based on a holistic approach that places femicide in the context of crimes against persons, incorporates biology and neuroscience approaches, and expands the current cultural explanations of femicide.