Multiple sclerosis decreases explicit counterfactual processing and risk taking in decision making.

Détails

Ressource 1Télécharger: BIB_FE5B1827B7E7.P001.pdf (560.26 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_FE5B1827B7E7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Multiple sclerosis decreases explicit counterfactual processing and risk taking in decision making.
Périodique
Plos One
Auteur(s)
Simioni S., Schluep M., Bault N., Coricelli G., Kleeberg J., Du Pasquier R.A., Gschwind M., Vuilleumier P., Annoni J.M.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
7
Numéro
12
Pages
e50718
Langue
anglais
Notes
Publication types: Journal Article
Résumé
INTRODUCTION: Deficits in decision making (DM) are commonly associated with prefrontal cortical damage, but may occur with multiple sclerosis (MS). There are no data concerning the impact of MS on tasks evaluating DM under explicit risk, where different emotional and cognitive components can be distinguished.
METHODS: We assessed 72 relapsing-remitting MS (RRMS) patients with mild to moderate disease and 38 healthy controls in two DM tasks involving risk with explicit rules: (1) The Wheel of Fortune (WOF), which probes the anticipated affects of decisions outcomes on future choices; and (2) The Cambridge Gamble Task (CGT) which measures risk taking. Participants also underwent a neuropsychological and emotional assessment, and skin conductance responses (SCRs) were recorded.
RESULTS: In the WOF, RRMS patients showed deficits in integrating positive counterfactual information (p<0.005) and greater risk aversion (p<0.001). They reported less negative affect than controls (disappointment: p = 0.007; regret: p = 0.01), although their implicit emotional reactions as measured by post-choice SCRs did not differ. In the CGT, RRMS patients differed from controls in quality of DM (p = 0.01) and deliberation time (p = 0.0002), the latter difference being correlated with attention scores. Such changes did not result in overall decreases in performance (total gains).
CONCLUSIONS: The quality of DM under risk was modified by MS in both tasks. The reduction in the expression of disappointment coexisted with an increased risk aversion in the WOF and alexithymia features. These concomitant emotional alterations may have implications for better understanding the components of explicit DM and for the clinical support of MS patients.
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2013 18:25
Dernière modification de la notice
20/08/2019 17:28
Données d'usage