Human phagocyte oxidative burst activation by BCG, M. leprae, and atypical mycobacteria: defective activation by M. leprae is not reversed by interferon gamma.

Détails

ID Serval
serval:BIB_FE40E3C89CC6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Human phagocyte oxidative burst activation by BCG, M. leprae, and atypical mycobacteria: defective activation by M. leprae is not reversed by interferon gamma.
Périodique
Cellular Immunology
Auteur(s)
Launois P., Maillere B., Dieye A., Sarthou J.L., Bach M.A.
ISSN
0008-8749 (Print)
ISSN-L
0008-8749
Statut éditorial
Publié
Date de publication
1989
Volume
124
Numéro
1
Pages
168-174
Langue
anglais
Résumé
The activation of the phagocyte oxidative respiratory burst by various mycobacteria was evaluated in an in vitro assay, by measuring the chemiluminescence, associated to the release of oxidizing species, generated by normal human whole blood phagocytes. All mycobacterium species, except Mycobacterium leprae, induced a significant chemiluminescence response. The strongest stimulus was provided by BCG, followed by M. triviale, M. chelonei, and M. fortuitum. M. kansasii, M. intracellulare, and M. lepraemurium elicited a weak response, although higher than that triggered by M. leprae. Both polymorphonuclear and mononuclear cells contributed to the whole blood cell chemiluminescence stimulated by mycobacteria, mononuclear cells being more efficient on a per cell basis. Phagocyte activation by recombinant interferon gamma did not improve M. leprae ability to trigger a significant chemiluminescence response. The failure of M. leprae and of some atypical mycobacteria to stimulate a strong phagocyte oxidative respiratory burst may have some relevance to their pathogenicity.
Mots-clé
Adult, Free Radicals, Humans, Interferon-gamma, Recombinant/pharmacology, Luminescent Measurements, Mycobacteria, Atypical/pathogenicity, Mycobacterium/pathogenicity, Mycobacterium bovis/pathogenicity, Mycobacterium leprae/pathogenicity, Oxidation-Reduction, Phagocytes/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 12:06
Dernière modification de la notice
20/08/2019 17:28
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