Functional signatures of protective antiviral T-cell immunity in human virus infections.

Détails

ID Serval
serval:BIB_FE2B6D903135
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Functional signatures of protective antiviral T-cell immunity in human virus infections.
Périodique
Immunological Reviews
Auteur(s)
Harari A., Dutoit V., Cellerai C., Bart P.A., Du Pasquier R.A., Pantaleo G.
ISSN
0105-2896[print], 0105-2896[linking]
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
211
Pages
236-254
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The most common human viruses have different abilities to establish persistent chronic infection. Virus-specific T-cell responses are critical in the control of virus replication and in the prevention of disease in chronic infection. A large number of phenotypic markers and a series of functions have been used to characterize virus-specific CD4+ and CD8+ T-cell responses, and these studies have shown great phenotypic and functional heterogeneity of the T-cell responses against different viruses. The heterogeneity of the T-cell response has been proposed to be specific to each virus. However, over the past 2 years, several studies have provided evidence that the phenotypic and functional heterogeneity of CD4+ and CD8+ T-cell responses is predominantly regulated by the levels of antigen load. The levels of antigen load modulate the phenotypic and functional patterns of the T-cell response within the same virus infection. Furthermore, the functional characterization of virus-specific CD4+ and CD8+ T-cell responses has identified signatures of protective antiviral immunity. Polyfunctional, i.e. interleukin-2 and interferon-gamma (IFN-gamma) secretion and proliferation, and not monofunctional, i.e. IFN-gamma secretion, CD4+ and CD8+ T-cell responses represent correlates of protective antiviral immunity in chronic virus infections.
Mots-clé
Acute Disease, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Chronic Disease, Humans, Immunity, Cellular/immunology, Lymphocyte Activation, Virus Diseases/immunology, Virus Diseases/virology
Pubmed
Web of science
Création de la notice
25/01/2008 14:56
Dernière modification de la notice
20/08/2019 16:28
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