Mechanisms regulating T-cell infiltration and activity in solid tumors.

Détails

ID Serval
serval:BIB_FE2398AAD635
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Mechanisms regulating T-cell infiltration and activity in solid tumors.
Périodique
Annals of oncology
Auteur(s)
Lanitis E., Dangaj D., Irving M., Coukos G.
ISSN
1569-8041 (Electronic)
ISSN-L
0923-7534
Statut éditorial
Publié
Date de publication
01/12/2017
Peer-reviewed
Oui
Volume
28
Numéro
suppl_12
Pages
xii18-xii32
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
T-lymphocytes play a critical role in cancer immunity as evidenced by their presence in resected tumor samples derived from long-surviving patients, and impressive clinical responses to various immunotherapies that reinvigorate them. Indeed, tumors can upregulate a wide array of defense mechanisms, both direct and indirect, to suppress the ability of Tcells to reach the tumor bed and mount curative responses upon infiltration. In addition, patient and tumor genetics, previous antigenic experience, and the microbiome, are all important factors in shaping the T-cell repertoire and sensitivity to immunotherapy. Here, we review the mechanisms that regulate T-cell homing, infiltration, and activity within the solid tumor bed. Finally, we summarize different immunotherapies and combinatorial treatment strategies that enable the immune system to overcome barriers for enhanced tumor control and improved patient outcome.
Mots-clé
Humans, Immunotherapy/methods, Lymphocytes, Tumor-Infiltrating/immunology, Neoplasms/immunology, Neoplasms/therapy, T-Lymphocytes/immunology, T cells, cancer, immunotherapy, tumor microenvironment
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/10/2017 8:14
Dernière modification de la notice
20/08/2019 16:28
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