ATM haplotypes and breast cancer risk in Jewish high-risk women

Détails

ID Serval
serval:BIB_FE15C78E85AB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
ATM haplotypes and breast cancer risk in Jewish high-risk women
Périodique
British Journal of Cancer
Auteur(s)
Koren  M., Kimmel  G., Ben-Asher  E., Gal  I., Papa  M. Z., Beckmann  J. S., Lancet  D., Shamir  R., Friedman  E.
ISSN
0007-0920 (Print)
Statut éditorial
Publié
Date de publication
05/2006
Volume
94
Numéro
10
Pages
1537-43
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 22
Résumé
While genetic factors clearly play a role in conferring breast cancer risk, the contribution of ATM gene mutations to breast cancer is still unsettled. To shed light on this issue, ATM haplotypes were constructed using eight SNPs spanning the ATM gene region (142 kb) in ethnically diverse non-Ashkenazi Jewish controls (n=118) and high-risk (n=142) women. Of the 28 haplotypes noted, four were encountered in frequencies of 5% or more and accounted for 85% of all haplotypes. Subsequently, ATM haplotyping of high-risk, non-Ashkenazi Jews was performed on 66 women with breast cancer and 76 asymptomatic. One SNP (rs228589) was significantly more prevalent among breast cancer cases compared with controls (P=4 x 10(-9)), and one discriminative ATM haplotype was significantly more prevalent among breast cancer cases (33.3%) compared with controls (3.8%), (P< or =10(-10)). There was no significant difference in the SNP and haplotype distribution between asymptomatic high-risk and symptomatic women as a function of disease status. We conclude that a specific ATM SNP and a specific haplotype are associated with increased breast cancer risk in high-risk non-Ashkenazi Jews.
Mots-clé
Adult Aged Ataxia Telangiectasia/genetics Breast Neoplasms/*genetics Case-Control Studies Cell Cycle Proteins/*genetics DNA-Binding Proteins/*genetics Female Haplotypes/*genetics Humans Israel/ethnology Jews/*genetics Middle Aged Polymorphism, Single Nucleotide/*genetics Protein-Serine-Threonine Kinases/*genetics Risk Factors Tumor Suppressor Proteins/*genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 17:18
Dernière modification de la notice
20/08/2019 17:28
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