Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Détails
ID Serval
serval:BIB_FD98D7DF3955
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Périodique
Nature
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
12/2002
Volume
420
Numéro
6917
Pages
788-94
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec 19-26
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec 19-26
Résumé
Do new synapses form in the adult cortex to support experience-dependent plasticity? To address this question, we repeatedly imaged individual pyramidal neurons in the mouse barrel cortex over periods of weeks. We found that, although dendritic structure is stable, some spines appear and disappear. Spine lifetimes vary greatly: stable spines, about 50% of the population, persist for at least a month, whereas the remainder are present for a few days or less. Serial-section electron microscopy of imaged dendritic segments revealed retrospectively that spine sprouting and retraction are associated with synapse formation and elimination. Experience-dependent plasticity of cortical receptive fields was accompanied by increased synapse turnover. Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.
Mots-clé
Absorptiometry, Photon
Aging/*physiology
Animals
Cerebral Cortex/*cytology/*physiology/ultrastructure
Dendrites/*physiology/ultrastructure
Kinetics
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Electron
*Neuronal Plasticity
Neurons, Afferent/cytology/physiology/ultrastructure
Perception/physiology
Pyramidal Cells/cytology/physiology/ultrastructure
Synapses/*physiology/ultrastructure
Time Factors
Pubmed
Web of science
Création de la notice
24/01/2008 15:40
Dernière modification de la notice
20/08/2019 17:28