SLP-2 is required for stress-induced mitochondrial hyperfusion.

Détails

ID Serval
serval:BIB_FD68C8D3A934
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
SLP-2 is required for stress-induced mitochondrial hyperfusion.
Périodique
The EMBO journal
Auteur⸱e⸱s
Tondera D., Grandemange S., Jourdain A., Karbowski M., Mattenberger Y., Herzig S., Da Cruz S., Clerc P., Raschke I., Merkwirth C., Ehses S., Krause F., Chan D.C., Alexander C., Bauer C., Youle R., Langer T., Martinou J.C.
ISSN
1460-2075 (Electronic)
ISSN-L
0261-4189
Statut éditorial
Publié
Date de publication
03/06/2009
Peer-reviewed
Oui
Volume
28
Numéro
11
Pages
1589-1600
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Mitochondria are dynamic organelles, the morphology of which results from an equilibrium between two opposing processes, fusion and fission. Mitochondrial fusion relies on dynamin-related GTPases, the mitofusins (MFN1 and 2) in the outer mitochondrial membrane and OPA1 (optic atrophy 1) in the inner mitochondrial membrane. Apart from a role in the maintenance of mitochondrial DNA, little is known about the physiological role of mitochondrial fusion. Here we report that mitochondria hyperfuse and form a highly interconnected network in cells exposed to selective stresses. This process precedes mitochondrial fission when it is triggered by apoptotic stimuli such as UV irradiation or actinomycin D. Stress-induced mitochondrial hyperfusion (SIMH) is independent of MFN2, BAX/BAK, and prohibitins, but requires L-OPA1, MFN1, and the mitochondrial inner membrane protein SLP-2. In the absence of SLP-2, L-OPA1 is lost and SIMH is prevented. SIMH is accompanied by increased mitochondrial ATP production and represents a novel adaptive pro-survival response against stress.
Mots-clé
Adenosine Triphosphate/metabolism, Animals, Cells, Cultured, Dactinomycin/toxicity, Fibroblasts/drug effects, Fibroblasts/physiology, Fibroblasts/radiation effects, GTP Phosphohydrolases/physiology, Membrane Proteins/physiology, Mice, Mitochondria/drug effects, Mitochondria/metabolism, Mitochondria/physiology, Mitochondria/radiation effects, Stress, Physiological, Ultraviolet Rays
Pubmed
Web of science
Création de la notice
13/04/2021 16:25
Dernière modification de la notice
08/02/2022 6:36
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