Les clones T, moyen d'exploration des antigenes mineurs impliques dans la reaction du greffon contre l'hote. [T clones, a means of exploring minor antigens involved in graft versus host reaction]

Détails

ID Serval
serval:BIB_FD613A476251
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Les clones T, moyen d'exploration des antigenes mineurs impliques dans la reaction du greffon contre l'hote. [T clones, a means of exploring minor antigens involved in graft versus host reaction]
Périodique
Presse Médicale
Auteur(s)
Miconnet  I.
ISSN
0755-4982 (Print)
Statut éditorial
Publié
Date de publication
12/1992
Volume
21
Numéro
41
Pages
1947-50
Notes
English Abstract
Journal Article --- Old month value: Dec 2
Résumé
During MHC-matched bone marrow transplantation, a graft-versus-host reaction (GVH) mediated by donor T lymphocytes and directed against host minor histocompatibility antigens may be observed. The establishment of T cell clones from GVH mice has enabled us to study minor antigens recognized during the reaction. Most of the T cell clones were Thyl+CD4+CD8-alpha beta+. Four minor, weakly polymorphic antigens, were evidenced; two of those antigens, recognized by CD4+ T cell clones, were implicated in GVH. One CD8+ T cell clone cannot provoke GVH mortality. The two "killer" clones express V beta 18 and V beta 2 TCR gene segments, respectively.
Mots-clé
Animals Antigens, CD4/immunology Base Sequence/genetics Bone Marrow Transplantation/*methods/mortality Clone Cells/physiology Graft vs Host Reaction/genetics/*immunology Mice Minor Histocompatibility Antigens/genetics/*immunology T-Lymphocytes/*physiology
Pubmed
Web of science
Création de la notice
25/01/2008 15:08
Dernière modification de la notice
20/08/2019 16:28
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