Post-exposure prophylaxis of HIV infection in healthcare workers: recommendations for the European setting

Détails

ID Serval
serval:BIB_FD5461EE8770
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Post-exposure prophylaxis of HIV infection in healthcare workers: recommendations for the European setting
Périodique
European Journal of Epidemiology
Auteur⸱e⸱s
Puro  V., Cicalini  S., De Carli  G., Soldani  F., Antunes  F., Balslev  U., Begovac  J., Bernasconi  E., Boaventura  J. L., Marti  M. C., Civljak  R., Evans  B., Francioli  P., Genasi  F., Larsen  C., Lot  F., Lunding  S., Marcus  U., Pereira  A. A., Thomas  T., Schonwald  S., Ippolito  G.
ISSN
0393-2990 (Print)
Statut éditorial
Publié
Date de publication
2004
Volume
19
Numéro
6
Pages
577-84
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Résumé
The European Commission funded a project for the standardisation of the management of occupational exposures to HIV/blood-borne infections and antiretroviral post-exposure prophylaxis (PEP) in Europe. Within this project, the following recommendations and rationale were formulated by experts representative of participating countries. Based on assessment of the exposure, material, and source characteristics, PEP should be started as soon as possible with any triple combination of antiretrovirals approved for the treatment of HIV-infected patients; initiation is discouraged after 72 hours Rapid HIV testing of the source could reduce inappropriate PEP. HIV testing should be performed at baseline, 4, 12, and 24 weeks, with additional clinical and laboratory monitoring of adverse reactions and potential toxicity at week 1 and 2. HIV resistance tests in the source and direct virus assays in the exposed HCW are not recommended routinely. These easy-to-use recommendations seek to maximise PEP effect while minimising its toxicity and inappropriate use.
Mots-clé
Anti-HIV Agents/*administration & dosage Europe/epidemiology HIV Infections/*epidemiology/*prevention & control Health Personnel/*statistics & numerical data Humans *Occupational Exposure Practice Guidelines
Pubmed
Web of science
Création de la notice
25/01/2008 17:07
Dernière modification de la notice
20/08/2019 16:28
Données d'usage