The potential of bronchoalveolar lavage in the prognosis and treatment of connective-vascular diseases.

Détails

ID Serval
serval:BIB_FD4BB400606A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The potential of bronchoalveolar lavage in the prognosis and treatment of connective-vascular diseases.
Périodique
Clinical and Experimental Rheumatology
Auteur⸱e⸱s
Spertini F., Aubert J.D., Leimgruber A.
ISSN
0392-856X
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
14
Numéro
6
Pages
681-688
Langue
anglais
Notes
Journal Article Review --- Old month value: Nov-Dec
Résumé
Interstitial lung disease (ILD) has a poor prognosis in a significant number of patients with connective vascular disease (CVD). By bronchoalveolar lavage fluid (BALF) analysis, ILD may be demonstrated in nearly half of patients with CVD prior to any alteration in lung function or chest radiograph. High neutrophil and eosinophil counts are usually associated with a high risk of functional deterioration, whereas the presence of increased lymphocytes correlates with a better outcome. Furthermore, initiation of therapy (steroids and/or cytotoxic agents) early in the course of disease is predictive of a better response. Cell differentials in bronchoalveolar lavage (BAL), together with measurements of cell by-products and techniques such as high resolution computed tomography, may contribute in the near future to help characterize those patients with the highest risks of evolution to pulmonary fibrosis, and to determine the most favorable time in the course of the disease for the initiation of therapy.
Mots-clé
Bronchoalveolar Lavage, Bronchoalveolar Lavage Fluid, Cell Division, Connective Tissue Diseases, Humans, Lung Diseases, Interstitial, Prognosis, Tomography, X-Ray Computed, Treatment Outcome, Vasculitis
Pubmed
Web of science
Création de la notice
25/01/2008 16:20
Dernière modification de la notice
20/08/2019 17:28
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