Oxidatively modified human low-density lipoprotein stimulates leukocyte adherence to the microvascular endothelium in vivo.

Détails

ID Serval
serval:BIB_FD3A5E7767DB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Oxidatively modified human low-density lipoprotein stimulates leukocyte adherence to the microvascular endothelium in vivo.
Périodique
Research In Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
Auteur(s)
Lehr H.A., Hübner C., Nolte D., Finckh B., Beisiegel U., Kohlschütter A., Messmer K.
ISSN
0300-9130 (Print)
ISSN-L
0300-9130
Statut éditorial
Publié
Date de publication
1991
Volume
191
Numéro
2
Pages
85-90
Langue
anglais
Résumé
In vitro studies indicate that oxidatively modified low-density lipoprotein (oxLDL) promotes leukocyte sticking to the vascular endothelium, a constant feature of early atherogenesis. Using intravital fluorescence microscopy in the dorsal skinfold chamber model in hamsters, we investigated whether systemic administration of human LDL, oxidized by Cu2+, elicited leukocyte/endothelium interaction in vivo. While no effect was seen after injection of native LDL, oxLDL administration resulted in an immediate induction of leukocyte rolling along the microvascular endothelium and subsequent firm sticking to the wall of postcapillary venules as well as arterioles. The presented model may provide an alternative experimental approach to long-term feeding studies with atherogenic diets for the in vivo investigation of leukocyte/endothelium interaction in early atherogenesis.
Mots-clé
Adult, Animals, Cell Adhesion/drug effects, Cricetinae, Endothelium, Vascular/drug effects, Free Radicals, Humans, Leukocytes/drug effects, Lipoproteins, LDL/pharmacology, Mesocricetus, Microcirculation, Microscopy, Fluorescence, Oxidation-Reduction, Skin/blood supply, Skin Window Technique
Pubmed
Création de la notice
25/11/2011 18:44
Dernière modification de la notice
20/08/2019 16:28
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