Atypical primary epithelioid hemangioendothelioma of the heart.

Détails

ID Serval
serval:BIB_FD123512130E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Atypical primary epithelioid hemangioendothelioma of the heart.
Périodique
Journal of Thoracic Oncology
Auteur(s)
Moulai N., Chavanon O., Guillou L., Noirclerc M., Blin D., Brambilla E., Lantuejoul S.
ISSN
1556-1380[electronic]
Statut éditorial
Publié
Date de publication
2006
Volume
1
Numéro
2
Pages
188-189
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
We report an unusual case of primary cardiac epithelioid hemangioendothelioma (EHE) with atypical features, which was treated by orthoptic transplantation with a good outcome for 10 years despite recurrent pulmonary and nodal metastases. EHE is a rare vascular tumor that belongs to the group of malignant proliferations from the new World Health Organization classification of soft tissue tumors. EHE may harbor atypical features that confer a more aggressive course, albeit better than that of conventional angiosarcomas. Histological examination of the primary cardiac tumor revealed a proliferation of large epithelioid tumor cells presenting atypical features and a mitotic index of 3 mitoses per 10 high power fields. In contrast, pulmonary metastases exhibited typical features of EHE, and CD 34 and CD 31 immunostainings strongly stained cytoplasmic vascular lumen. In this report, we illustrate the potential aggressiveness of the atypical variant of EHE and suggest that transplantation might be considered as an alternative therapy in the treatment of EHE of the heart.
Mots-clé
Biopsy, Diagnosis, Differential, Follow-Up Studies, Heart Neoplasms, Heart Transplantation, Hemangioendothelioma, Epithelioid, Humans, Male, Middle Aged
Pubmed
Web of science
Création de la notice
29/01/2008 18:33
Dernière modification de la notice
20/08/2019 16:28
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