Metabolism of oral glucose in children born small for gestational age: evidence for an impaired whole body glucose oxidation.

Détails

ID Serval
serval:BIB_FCCEF70EE7E2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Metabolism of oral glucose in children born small for gestational age: evidence for an impaired whole body glucose oxidation.
Périodique
Metabolism
Auteur(s)
Jornayvaz F.R., Selz R., Tappy L., Theintz G.E.
ISSN
0026-0495 (Print)
ISSN-L
0026-0495
Statut éditorial
Publié
Date de publication
2004
Volume
53
Numéro
7
Pages
847-851
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Epidemiological studies indicate that intrauterine growth restriction confers an increased risk of developing type 2 diabetes mellitus in subsequent life. Several studies have further documented the presence of insulin resistance in young adults or adolescent children born small for gestational age. Since most studies addressed postpubertal individuals, and since puberty markedly affects energy metabolism, we evaluated the disposal of oral glucose in a group including mainly prepubertal and early pubertal children with intrauterine growth restriction and in healthy age- and weight-matched control children. All children had an evaluation of their body composition by skinfold thickness measurements. They were then studied in standardized conditions and received 4 consecutive hourly loads of 180 mg glucose/kg body weight to reach a near steady state. Energy expenditure and substrate oxidation were evaluated during the fourth hour by indirect calorimetry. Compared to both age- and weight-matched children, children born small for gestational age had lower stature. Their energy expenditure was not significantly decreased, but they had lower glucose oxidation rates. These results indicate that metabolic alterations are present early in children born small for gestational age, and are possibly related to alterations of body composition.
Mots-clé
Adipose Tissue/physiology, Adolescent, Blood Glucose/metabolism, Body Composition/physiology, Body Height/physiology, Body Weight/physiology, Child, Energy Metabolism/physiology, Female, Fetal Growth Retardation/metabolism, Glucose/metabolism, Humans, Infant, Newborn, Infant, Small for Gestational Age/metabolism, Lipid Metabolism, Male, Oxidation-Reduction
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
20/08/2019 17:27
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