Resistance of human fungal pathogens to antifungal drugs
Détails
ID Serval
serval:BIB_FC977740CCD0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Resistance of human fungal pathogens to antifungal drugs
Périodique
Current Opinion in Microbiology
ISSN
1369-5274 (Print)
Statut éditorial
Publié
Date de publication
08/2002
Volume
5
Numéro
4
Pages
379-85
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Résumé
Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals. The isolation of various alleles of the gene encoding the target of azoles has enabled correlation of the appearance of resistance with distinct mutations. Resistance mechanisms to azoles also converge to the upregulation of multidrug transporter genes, whose products have the capacity to extrude from cells several chemically unrelated antifungal agents and toxic compounds. Genome-wide studies of azole-resistant isolates are now permitting a more comprehensive analysis of the impact of resistance on gene expression, and may deliver new clues to their mechanisms. Several laboratories are also exploring, as well as possible alternative resistance pathways, the role of biofilm formation by several fungal species in the development of resistance to various antifungals, including azoles.
Mots-clé
Antifungal Agents/*pharmacology
Azoles/*pharmacology
Drug Resistance, Fungal/*genetics
Fungal Proteins/genetics/metabolism
Gene Expression Regulation, Fungal
Humans
Mitosporic Fungi/*drug effects
Mycoses/*microbiology
Pubmed
Web of science
Création de la notice
25/01/2008 15:40
Dernière modification de la notice
20/08/2019 17:27