Low initial KCO predicts rapid FEV1 decline in pulmonary lymphangioleiomyomatosis

Détails

ID Serval
serval:BIB_FC5DC8422826
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Low initial KCO predicts rapid FEV1 decline in pulmonary lymphangioleiomyomatosis
Périodique
Respiratory Medicine
Auteur(s)
Lazor  R., Valeyre  D., Lacronique  J., Wallaert  B., Urban  T., Cordier  J. F.
ISSN
0954-6111
Statut éditorial
Publié
Date de publication
06/2004
Peer-reviewed
Oui
Volume
98
Numéro
6
Pages
536-41
Notes
Journal Article
Résumé
Pulmonary lymphangioleiomyomatosis (LAM) is a rare interstitial disorder affecting exclusively women, and leading to progressive deterioration of lung function. The disease course is highly variable from one patient to another, but no clinical predictor of rapid disease progression is currently available. To identify clinical variables, which could detect patients at risk for rapid lung function decline, we searched for correlations between the rate of forced expiratory volume in 1 s (FEV1) decline and clinical features at diagnosis in a retrospective series of 31 cases of LAM followed for > or = 1 yr. The mean FEV1 decline was 106+/-143 ml/yr or 3.4+/-4.6% predicted FEV1/yr. Among clinical features at diagnosis, only initial values of carbon monoxide transfer factor (TLCO, P = 0.006) and carbon monoxide transfer coefficient (KCO, P = 0.0001) were significantly correlated with the rate of FEV1 decline. Lung volumes and FEV1/forced vital capacity ratio at diagnosis were not predictive of rapid decline. No effect of previous smoking, contraceptive use or pregnancy on FEV1 decline could be detected. We conclude that low TLCO and KCO at the time of diagnosis are the best clinical predictors of rapid FEV1 decline in patients with LAM.
Mots-clé
Adult Age of Onset Carbon Monoxide/*metabolism Female Forced Expiratory Volume/physiology Humans Lung Neoplasms/*physiopathology Lymphangioleiomyomatosis/*physiopathology Vital Capacity/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/12/2008 11:58
Dernière modification de la notice
20/08/2019 16:27
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