TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function.

Détails

Ressource 1Télécharger: BIB_FC205F81134B.P001.pdf (936.49 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_FC205F81134B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function.
Périodique
Mucosal Immunology
Auteur(s)
Yadava K., Sichelstiel A., Luescher I.F., Nicod L.P., Harris N.L., Marsland B.J.
ISSN
1935-3456 (Electronic)
ISSN-L
1933-0219
Statut éditorial
Publié
Date de publication
2013
Volume
6
Numéro
1
Pages
83-92
Langue
anglais
Résumé
Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Although TSLP is also produced upon viral infection in vitro, the role of TSLP in antiviral immunity is unknown. In this study we report a novel role for TSLP in promoting viral clearance and virus-specific CD8+ T-cell responses during influenza A infection. Comparing the immune responses of wild-type and TSLP receptor (TSLPR)-deficient mice, we show that TSLP was required for the expansion and activation of virus-specific effector CD8+ T cells in the lung, but not the lymph node. The mechanism involved TSLPR signaling on newly recruited CD11b+ inflammatory dendritic cells (DCs) that acted to enhance interleukin-15 production and expression of the costimulatory molecule CD70. Taken together, these data highlight the pleiotropic activities of TSLP and provide evidence for its beneficial role in antiviral immunity.
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2013 10:05
Dernière modification de la notice
20/08/2019 17:27
Données d'usage