Global cardiovascular protection in chronic kidney disease.

Détails

ID Serval
serval:BIB_FC120CDB17EB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Global cardiovascular protection in chronic kidney disease.
Périodique
Nature reviews. Cardiology
Auteur(s)
Ruiz-Hurtado G., Sarafidis P., Fernández-Alfonso M.S., Waeber B., Ruilope L.M.
ISSN
1759-5010 (Electronic)
ISSN-L
1759-5002
Statut éditorial
Publié
Date de publication
10/2016
Peer-reviewed
Oui
Volume
13
Numéro
10
Pages
603-608
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The development and progression of cardiovascular disease (CVD) and renal disorders are very closely related. In patients with chronic kidney disease (CKD), therapies proven to protect the cardiovascular and renal systems simultaneously are generally used only at low doses or not at all. In particular, patients with CKD who receive angiotensin-converting-enzyme inhibitors, angiotensin-receptor blockers, or mineralocorticoid-receptor antagonists (MRAs) often do not experience complete blockade of the renin-angiotensin-aldosterone system, primarily owing to the risk of hyperkalaemia. In this Review, we provide an overview of the available treatments required for adequate cardiorenal protection in patients with CKD. Drugs such as β-blockers that interfere with renin secretion will be discussed, in addition to agents that can prevent hyperkalaemia, such as potassium binders and nonsteroidal MRAs. Furthermore, the current literature on the role of statins, in addition to new compounds and dosing recommendations for the treatment of patients with CKD will also be reviewed. Further studies with these new compounds and doses are needed to ascertain whether these approaches can improve the long-term cardiovascular and renal prognosis in patients with CKD.

Pubmed
Web of science
Création de la notice
13/10/2016 10:26
Dernière modification de la notice
20/08/2019 16:27
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