Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Détails
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_FBB1D626AA20
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Périodique
Ageing research reviews
ISSN
1872-9649 (Electronic)
ISSN-L
1568-1637
Statut éditorial
Publié
Date de publication
07/2021
Peer-reviewed
Oui
Volume
68
Pages
101343
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary disease. Hypoxia is pivotal to the pathogeneses of myriad neurological disorders, including Alzheimer's, Parkinson's and other age-related neurodegenerative diseases. Conversely, reduced environmental oxygen, e.g. sojourns or residing at high altitudes, may impart favorable effects on aging and mortality. Moreover, controlled hypoxia exposure may represent a treatment strategy for age-related neurological disorders. This review discusses evidence of hypoxia's beneficial vs. detrimental impacts on the aging brain and the molecular mechanisms that mediate these divergent effects. It draws upon an extensive literature search on the effects of hypoxia/altitude on brain aging, and detailed analysis of all identified studies directly comparing brain responses to hypoxia in young vs. aged humans or rodents. Special attention is directed toward the risks vs. benefits of hypoxia exposure to the elderly, and potential therapeutic applications of hypoxia for neurodegenerative diseases. Finally, important questions for future research are discussed.
Mots-clé
Aged, Aging, Brain, Humans, Hypoxia, Lung Diseases, Neuroprotection, Dementia, HIF, Hippocampus, Intermittent hypoxia, Mitochondria
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/04/2021 13:06
Dernière modification de la notice
23/01/2024 8:14