Causal Inference Methods to Integrate Omics and Complex Traits.

Détails

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Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_FB7006C4092B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Causal Inference Methods to Integrate Omics and Complex Traits.
Périodique
Cold Spring Harbor perspectives in medicine
Auteur⸱e⸱s
Porcu E., Sjaarda J., Lepik K., Carmeli C., Darrous L., Sulc J., Mounier N., Kutalik Z.
ISSN
2157-1422 (Electronic)
ISSN-L
2157-1422
Statut éditorial
Publié
Date de publication
03/05/2021
Peer-reviewed
Oui
Volume
11
Numéro
5
Pages
a040493
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Résumé
Major biotechnological advances have facilitated a tremendous boost to the collection of (gen-/transcript-/prote-/methyl-/metabol-)omics data in very large sample sizes worldwide. Coordinated efforts have yielded a deluge of studies associating diseases with genetic markers (genome-wide association studies) or with molecular phenotypes. Whereas omics-disease associations have led to biologically meaningful and coherent mechanisms, the identified (non-germline) disease biomarkers may simply be correlates or consequences of the explored diseases. To move beyond this realm, Mendelian randomization provides a principled framework to integrate information on omics- and disease-associated genetic variants to pinpoint molecular traits causally driving disease development. In this review, we show the latest advances in this field, flag up key challenges for the future, and propose potential solutions.
Mots-clé
Biomarkers, Biotechnology, Disease/etiology, Disease/genetics, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Phenotype
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/08/2020 15:36
Dernière modification de la notice
01/08/2023 5:55
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