Use of positron emission tomography (PET) in stereotactic conditions for brain biopsy

Détails

ID Serval
serval:BIB_FB32476B63DF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Use of positron emission tomography (PET) in stereotactic conditions for brain biopsy
Périodique
Acta Neurochirurgica
Auteur⸱e⸱s
Pirotte  B., Goldman  S., Bidaut  L. M., Luxen  A., Stanus  E., Brucher  J. M., Baleriaux  D., Brotchi  J., Levivier  M.
ISSN
0001-6268
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
134
Numéro
1-2
Pages
79-82
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
In order to take advantage of the metabolic information provided by positron emission tomography (PET) in cases of brain tumour, we have developed a technique to integrate PET images routinely in the planning of stereotactic brain biopsy. We used stereotactic PET with [18F]-labelled fluorodeoxyglucose (PET-FDG) in 38 patients undergoing brain biopsy. To evaluate the contribution of PET-FDG in guiding brain biopsy, we analyzed the diagnosis provided by the 78 stereotactic trajectories obtained in these patients. We found that stereotactic PET-FDG seemed to provide more information in cases of anaplastic astrocytomas and glioblastomas than in low-grade gliomas. Our results also show that biopsy trajectories performed in areas where increased FDG uptake is found within the lesion boundaries always provide interpretable specimens; this was not the case for trajectories guided by CT only. Therefore, the routine integration PET-FDG in the planning of stereotactic brain biopsy may lead to a reduction in sampling. Recently, we also tested consecutive stereotactic PET with [11C]-labelled methionine (PET-Met) and PET-FDG. This technique allowed us to compare accurately the tumoural glucose metabolism and protein synthesis. Our results suggest that stereotactic PET may increase the diagnostic yield of brain biopsy and may improve the understanding of PET in neuro-oncology.
Mots-clé
Adult Aged Astrocytoma/pathology/radionuclide imaging Biopsy/*instrumentation Blood Glucose/*metabolism Brain/*pathology/radionuclide imaging Brain Neoplasms/*pathology/radionuclide imaging Deoxyglucose/analogs & derivatives/metabolism Energy Metabolism/*physiology Female Fluorodeoxyglucose F18 Glioblastoma/pathology/radionuclide imaging Glioma/pathology/radionuclide imaging Humans Male Methionine/metabolism Middle Aged Neoplasm Proteins/metabolism Stereotaxic Techniques/*instrumentation Tomography, Emission-Computed/*instrumentation
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
20/08/2019 17:26
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