Use of positron emission tomography (PET) in stereotactic conditions for brain biopsy
Détails
ID Serval
serval:BIB_FB32476B63DF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Use of positron emission tomography (PET) in stereotactic conditions for brain biopsy
Périodique
Acta Neurochirurgica
ISSN
0001-6268
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
134
Numéro
1-2
Pages
79-82
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Résumé
In order to take advantage of the metabolic information provided by positron emission tomography (PET) in cases of brain tumour, we have developed a technique to integrate PET images routinely in the planning of stereotactic brain biopsy. We used stereotactic PET with [18F]-labelled fluorodeoxyglucose (PET-FDG) in 38 patients undergoing brain biopsy. To evaluate the contribution of PET-FDG in guiding brain biopsy, we analyzed the diagnosis provided by the 78 stereotactic trajectories obtained in these patients. We found that stereotactic PET-FDG seemed to provide more information in cases of anaplastic astrocytomas and glioblastomas than in low-grade gliomas. Our results also show that biopsy trajectories performed in areas where increased FDG uptake is found within the lesion boundaries always provide interpretable specimens; this was not the case for trajectories guided by CT only. Therefore, the routine integration PET-FDG in the planning of stereotactic brain biopsy may lead to a reduction in sampling. Recently, we also tested consecutive stereotactic PET with [11C]-labelled methionine (PET-Met) and PET-FDG. This technique allowed us to compare accurately the tumoural glucose metabolism and protein synthesis. Our results suggest that stereotactic PET may increase the diagnostic yield of brain biopsy and may improve the understanding of PET in neuro-oncology.
Mots-clé
Adult
Aged
Astrocytoma/pathology/radionuclide imaging
Biopsy/*instrumentation
Blood Glucose/*metabolism
Brain/*pathology/radionuclide imaging
Brain Neoplasms/*pathology/radionuclide imaging
Deoxyglucose/analogs & derivatives/metabolism
Energy Metabolism/*physiology
Female
Fluorodeoxyglucose F18
Glioblastoma/pathology/radionuclide imaging
Glioma/pathology/radionuclide imaging
Humans
Male
Methionine/metabolism
Middle Aged
Neoplasm Proteins/metabolism
Stereotaxic Techniques/*instrumentation
Tomography, Emission-Computed/*instrumentation
Pubmed
Web of science
Création de la notice
20/01/2008 17:35
Dernière modification de la notice
20/08/2019 16:26