Restoration of frontal activation during a treatment with quetiapine : an fMRI study of blunted affect in schizophrenia
Détails
ID Serval
serval:BIB_FA8A34B8F9D1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Restoration of frontal activation during a treatment with quetiapine : an fMRI study of blunted affect in schizophrenia
Périodique
Progress in neuro-psychopharmacology & biological psychiatry
ISSN
0278-5846
Statut éditorial
Publié
Date de publication
2005
Volume
29
Numéro
1
Pages
21-6
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
This study investigated changes in cerebral activation related to emotion processing in schizophrenia patients with blunted or flat affect (FA+) during treatment with quetiapine. Using functional magnetic resonance imaging (fMRI), brain activation in 12 FA+ schizophrenia patients during passive viewing of sad film excerpts was studied before and after a median of 5.5-months treatment with quetiapine. Random-effects 'paired sample t-test' analyses of brain activation before quetiapine (contrast=sad-neutral, before-after) revealed significant activation in the brainstem (pons, medulla). After quetiapine, the same contrast showed significant prefrontal activation (BA 9, 10 and 11). Activation of key prefrontal areas involved in emotion processing and significant symptoms improvement as measured by the subjective rating scale and PANSS suggests the potential effect of quetiapine in improving blunted affect related symptoms (i.e., passive withdrawal, emotional withdrawal, social avoidance) in schizophrenia.
Mots-clé
Adult, Affect / drug effects, Affect / physiology, Antipsychotic Agents / therapeutic use, Dibenzothiazepines / therapeutic use, Echo-Planar Imaging, Emotions / physiology, Female, Frontal Lobe / physiopathology, Humans, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales, Schizophrenia / drug therapy, Schizophrenia / physiopathology, Schizophrenic Psychology
Pubmed
Création de la notice
24/06/2009 14:41
Dernière modification de la notice
20/08/2019 17:26