Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis.

Détails

ID Serval
serval:BIB_FA0462B7A50F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis.
Périodique
Endocrine
Auteur⸱e⸱s
Trimboli P., Crescenzi A., Castellana M., Giorgino F., Giovanella L., Bongiovanni M.
ISSN
1559-0100 (Electronic)
ISSN-L
1355-008X
Statut éditorial
Publié
Date de publication
03/2019
Peer-reviewed
Oui
Volume
63
Numéro
3
Pages
430-438
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Systematic Review
Publication Status: ppublish
Résumé
Italian consensus for the classification and reporting of thyroid cytology has proposed to discriminate the cancer prevalence of high (Tir 3B) vs. low (Tir 3A) risk indeterminate nodules. To obtain more robust evidence on this topic, we performed a meta-analysis of the Odds Ratio (OR) of malignancy of Tir 3B vs. Tir 3A nodules.
A comprehensive literature exploration of online databases was conducted until May 2018. Original articles reporting histology of nodules cytologically classified as Tir 3A and Tir 3B were eligible. Pooled cancer prevalence in Tir 3A and Tir 3B, and OR of Tir 3B vs. Tir 3A were calculated.
The search revealed 95 articles, and 10 were included for the meta-analysis. Overall, 1168 indeterminate lesions were reported (441 Tir 3A and 727 Tir 3B), of which 391 were cancers. The pooled cancer prevalence was 17% in Tir 3A and 47% in Tir 3B. The OR of Tir 3B vs. Tir 3A was 4.24 (95% CI 2.75 to 6.53) with mild heterogeneity and without publication bias. When we considered non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) as non-malignant, cancer rate was lower, and OR of Tir 3B against Tir 3A was 2.93 (95% CI 1.60 to 5.37), with no heterogeneity but with publication bias.
The Italian system for thyroid cytology is reliable to assess indeterminate lesions at low and high risk, being Tir 3B associated with a cancer risk significantly higher than Tir 3A, also when considering NIFTP as non-malignant entity.
Mots-clé
Humans, Thyroid Gland/pathology, Thyroid Neoplasms/diagnosis, Thyroid Neoplasms/pathology, Thyroid Nodule/diagnosis, Thyroid Nodule/pathology, Carcinoma, Fine-needle aspiration (FNA), Indeterminate nodules, Risk of malignancy, Thyroid
Pubmed
Web of science
Création de la notice
11/12/2018 9:16
Dernière modification de la notice
03/05/2020 6:02
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