Neuroendocrine regulation and central dopamine (DA) systems in physical and psychological stress

Détails

ID Serval
serval:BIB_F9EB29926280
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Neuroendocrine regulation and central dopamine (DA) systems in physical and psychological stress
Périodique
Journal de Physiologie
Auteur⸱e⸱s
Monnet F., Lichtensteiger W.
ISSN
0928-4257
ISSN-L
0021-7948
Statut éditorial
Publié
Date de publication
1980
Volume
76
Numéro
3
Pages
273-275
Langue
anglais
Notes
Journal Article
Résumé
Physical and psychological stress cause different patterns of changes in the fluorescence intensity of nigral and tuberoinfundibular DA neurons which point to changes in neuronal activity. In order to investigate possible interactions between alpha-MSH (alpha-melanotropin) and DA systems in stress, systemic and intraventricular injections of antiserum against alpha-MSH were made. The functional state of DA neurons was assessed by histochemical microfluorimetry and hormone levels were measured by radioimmunossay. Antiserum against alpha-MSH was found to affect the functional state of DA neurons, but only thorugh the intravenous route. Under physical stress i.v. injection of antiserum against alpha-MSH was accompanied by elevated levels of activity of the DA neurons of the substantia nigra. An intraventricular injection of the same antiserum was ineffective. In psychological stress, an effect was again seen only after intravenous injection of antiserum against alpha-MSH. In this situation, the activity in DA cell groups of the substantia nigra, ventral tegmental area and tubero-infundibular system was increased after antiserum injection. Possible influences from manipulations were checked; certain effects which depended upon experimental situation were noted. Our data suggest a modulatory influence of circulating alpha-MSH on the functional state of central DA systems.
Mots-clé
Animals Dopamine/*physiology Humans Immune Sera/pharmacology Male Melanocyte-Stimulating Hormones/immunology/*physiology Neurons/*physiology Rats Stress, Physiological/*physiopathology Stress, Psychological/*physiopathology
Pubmed
Web of science
Création de la notice
10/02/2009 13:05
Dernière modification de la notice
20/08/2019 16:25
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