Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.

Détails

ID Serval
serval:BIB_F9D66A53B36C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.
Périodique
EMBO Journal
Auteur⸱e⸱s
Itoh F., Itoh S., Goumans M.J., Valdimarsdottir G., Iso T., Dotto G.P., Hamamori Y., Kedes L., Kato M., ten Dijke Pt P.
ISSN
0261-4189 (Print)
ISSN-L
0261-4189
Statut éditorial
Publié
Date de publication
2004
Volume
23
Numéro
3
Pages
541-551
Langue
anglais
Résumé
Notch and bone morphogenetic protein signaling pathways are important for cellular differentiation, and both have been implicated in vascular development. In many cases the two pathways act similarly, but antagonistic effects have also been reported. The underlying mechanisms and whether this is caused by an interplay between Notch and BMP signaling is unknown. Here we report that expression of the Notch target gene, Herp2, is synergistically induced upon activation of Notch and BMP receptor signaling pathways in endothelial cells. The synergy is mediated via RBP-Jkappa/CBF-1 and GC-rich palindromic sites in the Herp2 promoter, as well as via interactions between the Notch intracellular domain and Smad that are stabilized by p/CAF. Activated Notch and its downstream effector Herp2 were found to inhibit endothelial cell (EC) migration. In contrast, BMP via upregulation of Id1 expression has been reported to promote EC migration. Interestingly, Herp2 was found to antagonize BMP receptor/Id1-induced migration by inhibiting Id1 expression. Our results support the notion that Herp2 functions as a critical switch downstream of Notch and BMP receptor signaling pathways in ECs.
Mots-clé
Animals, Bone Morphogenetic Protein Receptors, COS Cells, Cell Movement/genetics, Cell Movement/physiology, Cercopithecus aethiops, DNA-Binding Proteins/metabolism, Down-Regulation/physiology, Endothelial Cells/physiology, GC Rich Sequence/physiology, Humans, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Inhibitor of Differentiation Protein 1, Membrane Proteins/genetics, Membrane Proteins/metabolism, Mice, Nuclear Proteins/metabolism, Promoter Regions, Genetic/physiology, Receptors, Growth Factor/genetics, Receptors, Growth Factor/metabolism, Receptors, Notch, Repressor Proteins/metabolism, Signal Transduction/genetics, Signal Transduction/physiology, Smad Proteins, Trans-Activators/metabolism, Transcription Factors/metabolism, Up-Regulation/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:59
Dernière modification de la notice
20/08/2019 16:25
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