Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament gene.

Détails

ID Serval
serval:BIB_F9B0AF9BA5F6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament gene.
Périodique
Experimental Neurology
Auteur(s)
Vickers J.C., Lazzarini R.A., Riederer B.M., Morrison J.H.
ISSN
0014-4886 (Print)
ISSN-L
0014-4886
Statut éditorial
Publié
Date de publication
1995
Volume
136
Numéro
2
Pages
266-269
Langue
anglais
Résumé
Neurofilamentous changes in select groups of neurons are associated with the degenerative changes of many human age-related neurodegenerative diseases. To examine the possible effects of aging on the neuronal cytoskeleton containing human proteins, the retinas of transgenic mice expressing the gene for the human middle-sized neurofilament triplet were investigated at 3 or 12 months of age. Transgenic mice developed tangle-like neurofilamentous accumulations in a subset of retinal ganglion cells at 12 months of age. These neurofilamentous accumulations, which also involved endogenous neurofilament proteins, were present in the perikarya and proximal processes of large ganglion cells and were predominantly located in peripheral retina. The presence of the human protein may thus confer vulnerability of the cytoskeleton to age-related alterations in this specific retinal cell type and may serve as a model for similar cellular changes associated with Alzheimer's disease and glaucoma.
Mots-clé
Aging/physiology, Animals, Gene Expression/genetics, Humans, Immunohistochemistry, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurofilament Proteins/biosynthesis, Neurofilament Proteins/genetics, Retinal Ganglion Cells/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:34
Dernière modification de la notice
20/08/2019 17:25
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