Antithrombotic treatment with direct-acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis.

Détails

ID Serval
serval:BIB_F99020497B70
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antithrombotic treatment with direct-acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis.
Périodique
Liver international : official journal of the International Association for the Study of the Liver
Auteur(s)
De Gottardi A., Trebicka J., Klinger C., Plessier A., Seijo S., Terziroli B., Magenta L., Semela D., Buscarini E., Langlet P., Görtzen J., Puente A., Müllhaupt B., Navascuès C., Nery F., Deltenre P., Turon F., Engelmann C., Arya R., Caca K., Peck-Radosavljevic M., Leebeek FWG, Valla D., Garcia-Pagan J.C.
Collaborateur(s)
VALDIG Investigators
Contributeur(s)
Grønbaek H., Beer J.H., Genescà J., Hidalgo C., Vila C., Mihailovic J., Piscaglia F., Lasser L., Fernandez-Bermejo M., Procopet B., Schouten J., Spahr L., Sanchez J.L., Zipprich A., Sekhar M., Hernandez-Guerra M., Laguna La, Nevens F., Ferreira C.N., Heneghan M., Albillos A., Llop E., Dell'Era A., La Mura V., Primignani M., Senzolo M., Escarda A., de Mallorca P., Riggio O., Murad S.D., Haas S., Bureau C., Berenguer M.
ISSN
1478-3231 (Electronic)
ISSN-L
1478-3223
Statut éditorial
Publié
Date de publication
05/2017
Peer-reviewed
Oui
Volume
37
Numéro
5
Pages
694-699
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Direct-acting oral anticoagulants (DOACs) are used in patients with splanchnic vein thrombosis (SVT) and cirrhosis, but evidence for safety and efficacy in this setting is limited. Our aim was to identify indications and reasons for starting or switching to DOACs and to report adverse effects, complications and short-term outcome.
Data collection including demographic information, laboratory values, treatment and complications through the Vascular Liver Disease Interest Group Consortium.
Forty-five centres (90%) of the consortium completed the initial eCRF. We report here a series of 94 patients from 17 centres. Thirty-six patients (38%) had cirrhosis. Child-Pugh score was 6 (range 5-8), and MELD score 10.2 (range 6-19). Indications for anticoagulation were splanchnic vein thrombosis (75%), deep vein thrombosis (5%), atrial fibrillation (14%) and others (6%). DOACs used were rivaroxaban (83%), dabigatran (11%) and apixaban (6%). Patients were followed up for a median duration of 15 months (cirrhotic) and 26.5 months (non-cirrhotic). Adverse events occurred in 17% of patients and included one case of recurrent portal vein thrombosis and five cases of bleeding. Treatment with DOACs was stopped in three cases. The major reasons for choosing DOACs were no need for monitoring or inadequacy of INR to guide anticoagulation in cirrhotic patients. Renal and liver function did not change during treatment.
A consistent number of patients with SVT and/or cirrhosis are currently treated with DOACs, which seem to be effective and safe. These data provide a basis for performing randomized clinical trials of DOACs vs. low molecular weight heparin or vitamin K antagonists.

Pubmed
Web of science
Création de la notice
01/11/2016 19:49
Dernière modification de la notice
20/08/2019 17:25
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