Averting inflammation by targeting the cytokine environment.

Détails

ID Serval
serval:BIB_F94A4794EDB8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Averting inflammation by targeting the cytokine environment.
Périodique
Nature Reviews. Drug Discovery
Auteur⸱e⸱s
Kopf M., Bachmann M.F., Marsland B.J.
ISSN
1474-1784[electronic], 1474-1776[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
9
Numéro
9
Pages
703-718
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Cytokines are key instigators and regulators of immune responses and therefore hold great potential as targets for new therapeutic strategies. However, the selection of which cytokines to target, and in particular the identification of which cytokines regulate the rate-limiting steps of disease pathways, is crucial to the success of such strategies. Moreover, balancing the need for ablating pathological inflammatory responses and simultaneously maintaining the ability to control infectious agents is a key consideration. Recent advances in our understanding of cytokine networks, as well as technical progress in blocking cytokines in vivo, are likely to be a source for new drugs that can control chronic inflammatory diseases.
Mots-clé
Animals, Chronic Disease, Cytokines/drug effects, Cytokines/metabolism, Drug Delivery Systems, Drug Design, Humans, Inflammation/drug therapy, Inflammation/physiopathology
Pubmed
Web of science
Création de la notice
28/02/2011 14:21
Dernière modification de la notice
20/08/2019 16:25
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