Breast cancer is the most frequent cancer among women. Screening programs are able to diagnose early lesions in an infra-clinic state. Percutaneous procedures are simple to do and well tolerated by women, they provide an histological diagnosis. This way of doing may reensure rapidly, without a surgical approach, the women with benign lesions. In cases of invasive cancers, percutaneous procedures are also able to optimize the ongoing therapeutic strategy. The type of the radiological anomaly determines the technical guidage of the procedure and the type of material. Ultrasonographic guidage is used for opacities and needles of small size can be used (micro-biopsy). With microcalcifications, the guidage is made with mammographic stereotaxis, these lesions are usually complex and they need needles of big size (macrobiopsy).