Therapeutic Targeting of the Tumor Microenvironment.

Détails

ID Serval
serval:BIB_F799CD903FA0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Therapeutic Targeting of the Tumor Microenvironment.
Périodique
Cancer discovery
Auteur(s)
Bejarano L., Jordāo MJC, Joyce J.A.
ISSN
2159-8290 (Electronic)
ISSN-L
2159-8274
Statut éditorial
Publié
Date de publication
04/2021
Peer-reviewed
Oui
Volume
11
Numéro
4
Pages
933-959
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical roles of the TME in regulating tumor progression and modulating response to standard-of-care therapies. Here, we summarize the current knowledge regarding the most advanced TME-directed therapies, which have either been clinically approved or are currently being evaluated in trials, including immunotherapies, antiangiogenic drugs, and treatments directed against cancer-associated fibroblasts and the extracellular matrix. We also discuss some of the challenges associated with TME therapies, and future perspectives in this evolving field. SIGNIFICANCE: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/04/2021 14:50
Dernière modification de la notice
08/05/2021 6:32
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