Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters.
Détails
ID Serval
serval:BIB_F71C4A0140C0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters.
Périodique
Blood
ISSN
1528-0020 (Electronic)
ISSN-L
0006-4971
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
120
Numéro
7
Pages
1466-1469
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Inactivating mutations of the Ten-Eleven Translocation 2 (TET2) gene were first identified in myeloid malignancies and more recently in peripheral T-cell lymphomas (PTCLs). In the present study, we investigated the presence of TET2 coding sequence mutations and their clinical relevance in a large cohort of 190 PTCL patients. TET2 mutations were identified in 40 of 86 (47%) cases of angioimmunoblastic T-cell lymphoma (AITL) and in 22 of 58 (38%) cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), but were absent in all other PTCL entities, with the exception of 2 of 10 cases of enteropathy-associated T-cell lymphoma. Among PTCL-NOS, a heterogeneous group of lymphoma-comprising cases likely to derive from Th follicular (T(FH)) cells similarly to AITL, TET2 mutations were more frequent when PTCL-NOS expressed T(FH) markers and/or had features reminiscent of AITL (58% vs 24%, P = .01). In the AITL and PTCL-NOS subgroups, TET2 mutations were associated with advanced-stage disease, thrombocytopenia, high International Prognostic Index scores, and a shorter progression-free survival.
Mots-clé
Aged, DNA-Binding Proteins/genetics, Female, Humans, Lymphoma, T-Cell, Peripheral/genetics, Lymphoma, T-Cell, Peripheral/immunology, Male, Mutation/genetics, Proto-Oncogene Proteins/genetics, Recurrence, T-Lymphocytes, Helper-Inducer/immunology, T-Lymphocytes, Helper-Inducer/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/09/2012 15:58
Dernière modification de la notice
20/08/2019 17:23