Trabecular Bone Score (TBS) Predicts Fracture in Ankylosing Spondylitis: The Manitoba BMD Registry.

Détails

ID Serval
serval:BIB_F6D0184CB929
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Trabecular Bone Score (TBS) Predicts Fracture in Ankylosing Spondylitis: The Manitoba BMD Registry.
Périodique
Journal of clinical densitometry
Auteur⸱e⸱s
Richards C., Hans D., Leslie W.D.
ISSN
1094-6950 (Print)
ISSN-L
1094-6950
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
23
Numéro
4
Pages
543-548
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Ankylosing spondylitis (AS) is a chronic inflammatory disease of the spine characterized among other features by spinal boney proliferation, back pain, loss of flexibility, and increased fracture risk. Overlying bone limits the utility of bone mineral density (BMD) by dual X-ray absorptiometry (DXA) in the spine. Trabecular bone score (TBS) is a bone texture measurement derived from the spine DXA image that indicates bone quality and fracture risk independent of BMD.
Using the Manitoba Bone Density Program database, patients with diagnosis codes for ankylosing spondylitis, baseline DXA and lumbar spine TBS were identified. Incident nontraumatic fractures (major osteoporotic [MOF], clinical spine, hip, and all fracture) were identified from population based databases. Cox-proportional hazard models are presented.
We identified 188 patients with diagnosed AS. TBS was lower in those with incident MOF (1.278 ± 0.126, compared to 1.178 ± 0.136, p < 0.001). Unadjusted TBS and FRAX-MOF-BMD adjusted predicted major osteoporotic fracture (N = 19) (hazard ratio [HR] 2.04, 95% confidence interval [CI]: 1.28-2.26, p = 0.003; HR 1.81, 95% CI: 1.11-2.96, p = 0.018). TBS unadjusted and FRAX-MOF-BMD adjusted also predicted clinical spine fracture (N = 7) (HR 2.50, 95% CI: 1.17-5.37; p = 0.019; HR 2.40 95% CI: 1.1-5.25; p = 0.028). Higher HRs were observed for prediction of hip fracture (N = 6), but these did not achieve statistical significance (FRAX-adjusted HR 1.74, 95% 0.73-4.17; p = 0.211). Unadjusted models show TBS was predictive of all fracture (N = 27) (HR 1.60, 95% CI: 1.08-2.39; p = 0.020), which was borderline significant after adjustment for FRAX-MOF-BMD (HR 1.51, 95% CI: 1.00-2.29; p = 0.052).
We report the first analysis of TBS for fracture prediction as an incident event in AS. TBS independently predicted major osteoporotic and clinical spine fracture in AS independent of FRAX.
Mots-clé
Absorptiometry, Photon, Bone Density, Cancellous Bone/diagnostic imaging, Cancellous Bone/pathology, Female, Humans, Lumbar Vertebrae/diagnostic imaging, Lumbar Vertebrae/pathology, Male, Manitoba, Middle Aged, Osteoporotic Fractures/diagnosis, Osteoporotic Fractures/etiology, Osteoporotic Fractures/pathology, Proportional Hazards Models, Registries, Risk Assessment, Spondylitis, Ankylosing/complications, Spondylitis, Ankylosing/diagnosis, Spondylitis, Ankylosing/pathology, Ankylosing spondylitis, DXA, fracture risk assessment, osteoporosis, other analysis/quantitation of bone
Pubmed
Web of science
Création de la notice
27/02/2020 13:40
Dernière modification de la notice
23/10/2021 5:38
Données d'usage