Three-Dimensional Measurement of Hepatocellular Carcinoma Ablation Zones and Margins for Predicting Local Tumor Progression.
Détails
ID Serval
serval:BIB_F6CDA40D63F2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Three-Dimensional Measurement of Hepatocellular Carcinoma Ablation Zones and Margins for Predicting Local Tumor Progression.
Périodique
Journal of vascular and interventional radiology
ISSN
1535-7732 (Electronic)
ISSN-L
1051-0443
Statut éditorial
Publié
Date de publication
07/2016
Peer-reviewed
Oui
Volume
27
Numéro
7
Pages
1038-1045.e2
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
To propose a postprocessing technique that measures tumor surface with insufficient ablative margins (≤ 5 mm) on magnetic resonance (MR) imaging to predict local tumor progression (LTP) following radiofrequency (RF) ablation.
A diagnostic method is proposed based on measurement of tumor surface with a margin ≤ 5 mm on MR imaging. The postprocessing technique includes fully automatic registration of pre- and post-RF ablation MR imaging, a semiautomatic segmentation of pre-RF ablation tumor and post-RF ablation volume, and a subsequent calculation of the three-dimensional exposed tumor surface area. The ability to use this surface margin ≤ 5 mm to predict local recurrence at 2 years was then tested on 16 patients with cirrhosis who were treated by RF ablation with a margin ≤ 5 mm in 2012: eight with LTP matched according to tumor size and number and α-fetoprotein level versus eight without local recurrence.
The error of estimated tumor surface with a margin ≤ 5 mm was less than 12%. Results of a log-rank test showed that patients with a tumor surface area > 425 mm(2) had a 2-year LTP rate of 77.5%, compared with 25% for patients with a tumor surface area ≤ 425 mm(2) (P = .018).
This proof-of-concept study proposes an accurate and reliable postprocessing technique to estimate tumor surface with insufficient ablative margins, and underscores the potential usefulness of tumor surface with a margin ≤ 5 mm to stratify patients with HCC treated by RF ablation according to their risk of LTP.
A diagnostic method is proposed based on measurement of tumor surface with a margin ≤ 5 mm on MR imaging. The postprocessing technique includes fully automatic registration of pre- and post-RF ablation MR imaging, a semiautomatic segmentation of pre-RF ablation tumor and post-RF ablation volume, and a subsequent calculation of the three-dimensional exposed tumor surface area. The ability to use this surface margin ≤ 5 mm to predict local recurrence at 2 years was then tested on 16 patients with cirrhosis who were treated by RF ablation with a margin ≤ 5 mm in 2012: eight with LTP matched according to tumor size and number and α-fetoprotein level versus eight without local recurrence.
The error of estimated tumor surface with a margin ≤ 5 mm was less than 12%. Results of a log-rank test showed that patients with a tumor surface area > 425 mm(2) had a 2-year LTP rate of 77.5%, compared with 25% for patients with a tumor surface area ≤ 425 mm(2) (P = .018).
This proof-of-concept study proposes an accurate and reliable postprocessing technique to estimate tumor surface with insufficient ablative margins, and underscores the potential usefulness of tumor surface with a margin ≤ 5 mm to stratify patients with HCC treated by RF ablation according to their risk of LTP.
Mots-clé
Aged, Carcinoma, Hepatocellular/blood, Carcinoma, Hepatocellular/diagnostic imaging, Carcinoma, Hepatocellular/pathology, Carcinoma, Hepatocellular/surgery, Catheter Ablation/adverse effects, Disease Progression, Female, Humans, Image Interpretation, Computer-Assisted/methods, Imaging, Three-Dimensional/methods, Liver Neoplasms/blood, Liver Neoplasms/diagnostic imaging, Liver Neoplasms/pathology, Liver Neoplasms/surgery, Magnetic Resonance Imaging/methods, Male, Margins of Excision, Middle Aged, Neoplasm Recurrence, Local, Neoplasm, Residual, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Tumor Burden, alpha-Fetoproteins/metabolism
Pubmed
Web of science
Création de la notice
25/10/2017 14:49
Dernière modification de la notice
20/08/2019 17:23