From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome.

Détails

ID Serval
serval:BIB_F6BA6B08DA7D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome.
Périodique
Nature reviews. Neuroscience
Auteur(s)
Bagni C., Greenough W.T.
ISSN
1471-003X (Print)
ISSN-L
1471-003X
Statut éditorial
Publié
Date de publication
05/2005
Volume
6
Numéro
5
Pages
376-387
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Publication Status: ppublish
Résumé
The mental retardation protein FMRP is involved in the transport of mRNAs and their translation at synapses. Patients with fragile X syndrome, in whom FMRP is absent or mutated, show deficits in learning and memory that might reflect impairments in the translational regulation of a subset of neuronal mRNAs. The study of FMRP provides important insights into the regulation and functions of local protein synthesis in the neuronal periphery, and increases our understanding of how these functions can produce specific effects at individual synapses.

Mots-clé
Animals, Fragile X Mental Retardation Protein, Fragile X Syndrome/genetics, Fragile X Syndrome/metabolism, Fragile X Syndrome/pathology, Humans, Nerve Tissue Proteins/deficiency, Nerve Tissue Proteins/genetics, Nerve Tissue Proteins/physiology, Protein Transport/genetics, RNA-Binding Proteins/genetics, RNA-Binding Proteins/physiology, Ribonucleoproteins/genetics, Ribonucleoproteins/metabolism, Spinal Cord/abnormalities, Spinal Cord/metabolism
Pubmed
Création de la notice
06/03/2017 18:23
Dernière modification de la notice
20/08/2019 17:23
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