Clinical evaluation of targeting accuracy of gamma knife radiosurgery in trigeminal neuralgia.

Détails

ID Serval
serval:BIB_F66C73A6978A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical evaluation of targeting accuracy of gamma knife radiosurgery in trigeminal neuralgia.
Périodique
International Journal of Radiation Oncology, Biology, Physics
Auteur(s)
Massager N., Abeloos L., Devriendt D., Op de Beeck M., Levivier M.
ISSN
0360-3016 (Print)
ISSN-L
0360-3016
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
69
Numéro
5
Pages
1514-1520
Langue
anglais
Notes
Publication types: Evaluation Studies ; Journal Article
Publication Status: ppublish
Résumé
PURPOSE: The efficiency of radiosurgery is related to its highly precise targeting. We assessed clinically the targeting accuracy of radiosurgical treatment with the Leksell Gamma Knife for trigeminal neuralgia. We also studied the applied radiation dose within the area of focal contrast enhancement on the trigeminal nerve root following radiosurgery.
METHODS AND MATERIALS: From an initial group of 78 patients with trigeminal neuralgia treated with gamma knife radiosurgery using a 90-Gy dose, we analyzed a subgroup of 65 patients for whom 6-month follow-up MRI showed focal contrast enhancement of the trigeminal nerve. Follow-up MRI was spatially coregistered to the radiosurgical planning MRI. Target accuracy was assessed from deviation of the coordinates of the intended target compared with the center of enhancement on postoperative MRI. Radiation dose delivered at the borders of contrast enhancement was evaluated.
RESULTS: The median deviation of the coordinates between the intended target and the center of contrast enhancement was 0.91 mm in Euclidean space. The radiation doses fitting within the borders of the contrast enhancement of the trigeminal nerve root ranged from 49 to 85 Gy (median value, 77 +/- 8.7 Gy).
CONCLUSIONS: The median deviation found in clinical assessment of gamma knife treatment for trigeminal neuralgia is low and compatible with its high rate of efficiency. Focal enhancement of the trigeminal nerve after radiosurgery occurred in 83% of our patients and was not associated with clinical outcome. Focal enhancement borders along the nerve root fit with a median dose of 77 +/- 8.7 Gy.
Mots-clé
Adult, Aged, Aged, 80 and over, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Radiosurgery/instrumentation, Radiosurgery/standards, Radiotherapy Dosage, Trigeminal Nerve/pathology, Trigeminal Nerve/surgery, Trigeminal Nerve Diseases/etiology, Trigeminal Nerve Diseases/pathology, Trigeminal Neuralgia/pathology, Trigeminal Neuralgia/surgery
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
20/08/2019 17:22
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