Innappropriate renin secretion unmasked by captopril (SQ 14 225) in hypertension of chronic renal failure

Détails

ID Serval
serval:BIB_F5B4946CA42D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Innappropriate renin secretion unmasked by captopril (SQ 14 225) in hypertension of chronic renal failure
Périodique
Lancet
Auteur(s)
Brunner  H. R., Waeber B., Wauters  J. P., Turin G., McKinstry D., Gavras H.
ISSN
0140-6736
Statut éditorial
Publié
Date de publication
1978
Peer-reviewed
Oui
Volume
2
Numéro
8092 Pt 1
Pages
704-7
Langue
anglais
Notes
Journal Article
Résumé
Captopril (SQ 14 225), an orally active inhibitor of angiotensin-converting enzyme, was given to 7 hypertensive patients with chronic renal failure whose plasma-creatinine ranged from 1.5--7.4 mg/dl; whose plasma-renin activity was normal; whose hypertension was not controlled by previous therapy consisting in 5 patients of three or more antihypertensive drugs; and whose blood-pressures averaged 176/111 +/- 11/3 mm Hg. Inhibition of converting enzyme by oral captopril, 200 mg twice daily, reduced blood-pressure to 156/100 +/- 9/5 mm Hg. 5 patients needed additional treatment by frusemide 40--250 mg/day orally. With this combined regimen the blood-pressure of all patients averaged 126/85 +/- 4/3 mm Hg after 8 +/- 2 weeks of captopril. The drug was well tolerated. These results suggest that inhibition of angiotensin-converting enzyme with or without sodium depletion is an efficient treatment for hypertension associated with chronic renal failure. It appears that although renin levels in patients with this condition may be "normal", they are inappropriate in relation to the subtle degree of sodium retention that occurs with this disorder.
Mots-clé
Administration, OralAdult*Angiotensin-Converting Enzyme InhibitorsAntihypertensive Agents/administration & dosage/*therapeutic useBlood Pressure/drug effectsDrug Therapy, CombinationFemaleFurosemide/therapeutic useHumansHypertension, Renal/drug therapy/*etiologyKidney Failure, Chronic/*physiopathologyMaleMiddle AgedProline/administration & dosage/*analogs & derivatives/therapeutic useRenin/*secretionSodium/metabolism
Pubmed
Web of science
Création de la notice
04/03/2009 16:04
Dernière modification de la notice
20/08/2019 17:22
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