A proposal for an international retinoblastoma staging system.

Détails

ID Serval
serval:BIB_F5829B728EFE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A proposal for an international retinoblastoma staging system.
Périodique
Pediatric blood & cancer
Auteur⸱e⸱s
Chantada G., Doz F., Antoneli C.B., Grundy R., Clare Stannard F.F., Dunkel I.J., Grabowski E., Leal-Leal C., Rodríguez-Galindo C., Schvartzman E., Popovic M.B., Kremens B., Meadows A.T., Zucker J.M.
ISSN
1545-5009
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
47
Numéro
6
Pages
801-5
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study - Publication Status: ppublish
Résumé
BACKGROUND: Although intra-retinal tumor has long been staged presurgically according to the Reese-Ellsworth (R-E) system, retinoblastoma differs from other pediatric neoplasms in never having had a widely accepted classification system that encompasses the entire spectrum of the disease. Comparisons among studies that consider disease extension, risk factors for extra-ocular relapse, and response to therapy require a universally accepted staging system for extra-ocular disease. PROCEDURE: A committee of retinoblastoma experts from large centers worldwide has developed a consensus classification that can encompass all retinoblastoma cases and is presented herein. Patients are classified according to extent of disease and the presence of overt extra-ocular extension. In addition, a proposal for substaging considering histopathological features of enucleated specimens is presented to further discriminate between Stage I and II patients. RESULTS: The following is a summary of the classification system developed-Stage 0: Patients treated conservatively (subject to presurgical ophthalmologic classifications); Stage I: Eye enucleated, completely resected histologically; Stage II: Eye enucleated, microscopic residual tumor; Stage III: Regional extension [(a) overt orbital disease, (b) preauricular or cervical lymph node extension]; Stage IV: Metastatic disease [(a) hematogenous metastasis: (1) single lesion, (2) multiple lesions; (b) CNS extension: (1) prechiasmatic lesion, (2) CNS mass, (3) leptomeningeal disease]. A proposal is also presented for substaging of enucleated Stages I and II eyes. CONCLUSIONS: The proposed staging system is the product of an international effort to adopt a uniform staging system for patients with retinoblastoma to cover the whole spectrum of the disease.
Mots-clé
Humans, Neoplasm Staging, Retinal Neoplasms, Retinoblastoma
Pubmed
Web of science
Création de la notice
20/03/2008 9:34
Dernière modification de la notice
20/08/2019 16:22
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