Loss of egg yolk genes in mammals and the origin of lactation and placentation

Détails

Ressource 1Télécharger: BIB_F580CD5AAB45.P001.pdf (3052.57 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_F580CD5AAB45
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Loss of egg yolk genes in mammals and the origin of lactation and placentation
Périodique
PLoS Biology
Auteur(s)
Brawand D., Wahli W., Kaessmann H.
ISSN
1545-7885
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
6
Numéro
3
Pages
e63
Langue
anglais
Résumé
Embryonic development in nonmammalian vertebrates depends entirely on nutritional reserves that are predominantly derived from vitellogenin proteins and stored in egg yolk. Mammals have evolved new resources, such as lactation and placentation, to nourish their developing and early offspring. However, the evolutionary timing and molecular events associated with this major phenotypic transition are not known. By means of sensitive comparative genomics analyses and evolutionary simulations, we here show that the three ancestral vitellogenin-encoding genes were progressively lost during mammalian evolution (until around 30-70 million years ago, Mya) in all but the egg-laying monotremes, which have retained a functional vitellogenin gene. Our analyses also provide evidence that the major milk resource genes, caseins, which have similar functional properties as vitellogenins, appeared in the common mammalian ancestor approximately 200-310 Mya. Together, our data are compatible with the hypothesis that the emergence of lactation in the common mammalian ancestor and the development of placentation in eutherian and marsupial mammals allowed for the gradual loss of yolk-dependent nourishment during mammalian evolution
Mots-clé
Animals , Base Sequence , Caseins , Chickens , Egg Yolk , Evolution,Molecular , Female , Gene Silencing , genetics , Genome , Genomics , Lactation , Mammals , Marsupialia , metabolism , Milk , Molecular Sequence Data , Monotremata , Phosphoproteins , Phylogeny , Placentation , Pregnancy , Proteins , Selection (Genetics) , Sequence Alignment , Switzerland , Synteny , Vitellogenins
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2009 23:13
Dernière modification de la notice
20/08/2019 17:22
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