Clonal groupings in serogroup X Neisseria meningitidis.

Détails

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Accès restreint UNIL
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_F57C9E99D772
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clonal groupings in serogroup X Neisseria meningitidis.
Périodique
Emerging infectious diseases
Auteur⸱e⸱s
Gagneux S., Wirth T., Hodgson A., Ehrhard I., Morelli G., Kriz P., Genton B., Smith T., Binka F., Pluschke G., Achtman M.
ISSN
1080-6040
ISSN-L
1080-6040
Statut éditorial
Publié
Date de publication
05/2002
Peer-reviewed
Oui
Volume
8
Numéro
5
Pages
462-466
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although most European and American isolates were highly diverse, one clonal grouping was identified in sporadic disease and carrier strains isolated over the last 2 decades in the United Kingdom, the Netherlands, Germany, and the United States. In contrast to the diversity in the European and American isolates, most carrier and disease isolates recovered during the last 30 years in countries in the African meningitis belt belonged to a second clonal grouping. During the last decade, these bacteria have caused meningitis outbreaks in Niger and Ghana. These results support the development of a comprehensive conjugate vaccine that would include serogroup X polysaccharide.
Mots-clé
Africa/epidemiology, Alleles, Electrophoresis, Gel, Pulsed-Field, Europe/epidemiology, Humans, Meningococcal Infections/microbiology, Neisseria meningitidis/classification, Neisseria meningitidis/genetics, Neisseria meningitidis/isolation & purification, North America/epidemiology, Phylogeny, Retrospective Studies, Serotyping
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:49
Dernière modification de la notice
09/08/2024 15:51
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