Mitochondria: A master regulator in macrophage and T cell immunity.

Détails

ID Serval
serval:BIB_F5461A5E94DF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Mitochondria: A master regulator in macrophage and T cell immunity.
Périodique
Mitochondrion
Auteur(s)
Liu P.S., Ho P.C.
ISSN
1872-8278 (Electronic)
ISSN-L
1567-7249
Statut éditorial
Publié
Date de publication
07/2018
Peer-reviewed
Oui
Volume
41
Pages
45-50
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Orchestrating biological activities of immune cells through metabolic reprogramming reveals a new approach to harnessing immune responses. Increasing evidence reveals that the mitochondrion is a central regulator for modulating metabolic reprogramming and controlling immune cell activation and functions. In addition to supporting bioenergetic demands, the mitochondrion serves as a signaling platform through the generation of reactive oxygen species and metabolites of the tricarboxylic acid cycle to modulate signaling cascades controlling immune cell activation and immune responses. Herein, we discuss the mechanisms through which the mitochondrion acts as a master regulator to fine-tune immune responses elicited by macrophages and T cells.
Mots-clé
Animals, Energy Metabolism, Humans, Immunity, Innate/immunology, Macrophages/immunology, Metabolic Diseases/immunology, Metabolic Diseases/pathology, Mitochondria/immunology, Mitochondria/metabolism, Mitochondria/pathology, Signal Transduction, T-Lymphocytes/immunology, Cellular metabolism, Immunity, Macrophages, Mitochondria, PRRs, T cells
Pubmed
Web of science
Création de la notice
23/11/2017 22:19
Dernière modification de la notice
20/08/2019 17:22
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