Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations

Détails

ID Serval
serval:BIB_F53E1F0829F7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations
Périodique
International Archives of Occupational and Environmental Health
Auteur(s)
Hines Cynthia J., Hopf Nancy B., Deddens James A., Silva Manori J., Calafat Antonia M.
ISSN
1432-1246 (Electronic)
ISSN-L
0340-0131
Statut éditorial
Publié
Date de publication
04/2012
Peer-reviewed
Oui
Volume
85
Numéro
3
Pages
317-325
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Diisononyl phthalate (DiNP) is primarily used as a plasticizer in polyvinyl chloride (PVC) materials. While information is available on general population exposure to DiNP, occupational exposure data are lacking. We present DiNP metabolite urinary concentrations in PVC processing workers, estimate DiNP daily intake for these workers, and compare worker estimates to other populations.
We assessed DiNP exposure in participants from two companies that manufactured PVC materials, a PVC film manufacturer (n = 25) and a PVC custom compounder (n = 12). A mid-shift and end-shift urine sample was collected from each participant and analyzed for the DiNP metabolite mono(carboxy-isooctyl) phthalate (MCiOP). Mixed models were used to assess the effect on MCiOP concentrations of a worker being assigned to (1) a task using DiNP and (2) a shift where DiNP was used. A simple pharmacokinetic model was used to estimate DiNP daily intake from the MCiOP concentrations.
Creatinine-adjusted MCiOP urinary concentrations ranged from 0.42-80 μg/g in PVC film and from 1.11-13.4 μg/g in PVC compounding. PVC film participants who worked on a task using DiNP (n = 7) had the highest MCiOP geometric mean (GM) end-shift concentration (25.2 μg/g), followed by participants who worked on a shift where DiNP was used (n = 11) (17.7 μg/g) as compared to participants with no task (2.92 μg/g) or shift (2.08 μg/g) exposure to DiNP. The GM end-shift MCiOP concentration in PVC compounding participants (4.80 μg/g) was comparable to PVC film participants with no task or shift exposure to DiNP. Because no PVC compounding participants were assigned to tasks using DINP on the day sampled, DiNP exposure in this company may be underestimated. The highest DiNP intake estimate was 26 μg/kg/day.
Occupational exposure to DiNP associated with PVC film manufacturing tasks were substantially higher (sixfold to tenfold) than adult general population exposures; however, all daily intake estimates were less than 25% of current United States or European acceptable or tolerable daily intake estimates. Further characterization of DiNP occupational exposures in other industries is recommended.

Mots-clé
Adolescent, Adult, Biomarkers/urine, Chemical Industry, Environmental Monitoring, Female, Humans, Male, Middle Aged, Occupational Exposure/analysis, Phthalic Acids/pharmacokinetics, Phthalic Acids/urine, Polyvinyl Chloride, Young Adult
Pubmed
Web of science
Création de la notice
24/08/2011 17:17
Dernière modification de la notice
20/08/2019 17:22
Données d'usage