A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer.

Détails

ID Serval
serval:BIB_F4F6931A7659
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer.
Périodique
Nature Medicine
Auteur(s)
Farmer P., Bonnefoi H., Anderle P., Cameron D., Wirapati P., Wirapati P., Becette V., André S., Piccart M., Campone M., Brain E., Macgrogan G., Petit T., Jassem J., Bibeau F., Blot E., Bogaerts J., Aguet M., Bergh J., Iggo R., Delorenzi M.
ISSN
1546-170X (Electronic)
ISSN-L
1078-8956
Statut éditorial
Publié
Date de publication
2009
Volume
15
Numéro
1
Pages
68-74
Langue
anglais
Résumé
To better understand the relationship between tumor-host interactions and the efficacy of chemotherapy, we have developed an analytical approach to quantify several biological processes observed in gene expression data sets. We tested the approach on tumor biopsies from individuals with estrogen receptor-negative breast cancer treated with chemotherapy. We report that increased stromal gene expression predicts resistance to preoperative chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC) in subjects in the EORTC 10994/BIG 00-01 trial. The predictive value of the stromal signature was successfully validated in two independent cohorts of subjects who received chemotherapy but not in an untreated control group, indicating that the signature is predictive rather than prognostic. The genes in the signature are expressed in reactive stroma, according to reanalysis of data from microdissected breast tumor samples. These findings identify a previously undescribed resistance mechanism to FEC treatment and suggest that antistromal agents may offer new ways to overcome resistance to chemotherapy.
Mots-clé
Algorithms, Breast Neoplasms/diagnosis, Breast Neoplasms/drug therapy, Drug Resistance, Neoplasm/genetics, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Neoadjuvant Therapy, Oligonucleotide Array Sequence Analysis, Oncogenes/physiology, Predictive Value of Tests, Prognosis, Stromal Cells/metabolism, Stromal Cells/pathology
Pubmed
Web of science
Création de la notice
02/09/2011 19:52
Dernière modification de la notice
20/08/2019 17:21
Données d'usage