Psychometric schizotypy modulates levodopa effects on lateralized lexical decision performance

Détails

ID Serval
serval:BIB_F4D840F9A923
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Psychometric schizotypy modulates levodopa effects on lateralized lexical decision performance
Périodique
Journal of Psychiatric Research
Auteur⸱e⸱s
Mohr C., Krummenacher P., Landis T., Sandor P. S., Fathi M., Brugger P.
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
39
Numéro
3
Pages
241-250
Langue
anglais
Notes
0022-3956 (Print)
0022-3956 (Linking)
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Résumé
Emergence of psychotic thought has been related to a breakdown in left-hemisphere language dominance. Dopamine (DA) is implicated in both psychotic pathology and modulation of the semantic system. The present study explored whether controlled DA administration modulates basic language functions: (1) in general and/or (2) as a function of schizophrenia-associated thought. Forty healthy men performed a tachistoscopic lexical decision task. Participants' performance was also analyzed as a function of their positive (magical ideation, MI) and negative (physical anhedonia, PHYSAN) schizotypal features. Half of the subjects received 200 mg levodopa, the other half a placebo. Our findings showed that pharmacological treatment per se did not influence task performance, but influenced laterality patterns as a function of participants' schizotypal features. In the placebo, but not in the levodopa group, right hemisphere language contribution increased as a function of increasing MI scores. In the levodopa, but not in the placebo group, superior left hemisphere lexical decision performance was related to increasing PHYSAN scores. The findings from both substance groups suggest that in the healthy brain, a DA agonist restores left-hemispheric dominance for language by reducing right-hemispheric contribution with respect to a positive schizotypal trait and by increasing left-hemispheric specialization with respect to a negative schizotypal trait. We conjecture that the healthy brain compensates through intact neurochemical mechanisms an increased DA concentration, in particular for persons with elevated positive psychotic-like features.
Mots-clé
Adult Brain/metabolism/*physiopathology Cognition Disorders/diagnosis Dopamine/metabolism Dopamine Agonists/administration & dosage/*pharmacology Double-Blind Method Functional Laterality/*drug effects Humans Language Levodopa/administration & dosage/*pharmacology Male Psychometrics/*methods Questionnaires Schizotypal Personality Disorder/metabolism/*physiopathology Semantics Thinking
Création de la notice
17/01/2011 19:07
Dernière modification de la notice
20/08/2019 16:21
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